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3.
Endocrinol. diabetes nutr. (Ed. impr.) ; 67(2): 89-101, feb. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-187433

RESUMO

Antecedentes y objetivo: En el hipotálamo existen poblaciones neuronales involucradas en la regulación de la ingesta, destacando la ghrelina como hormona orexígena (estimula el apetito). Después de los diferentes procedimientos de cirugía bariátrica se han observado cambios en los niveles plasmáticos de ghrelina, siendo los resultados de los estudios contradictorios. Existen muchas lagunas en cuanto al papel que desempeña la ghrelina en el proceso de pérdida de peso después de cirugía bariátrica. Nuestro objetivo es describir el comportamiento de ghrelina en ayunas, comparando los cambios acontecidos en 2 técnicas quirúrgicas (bypass gástrico versus gastrectomía vertical) y su correlación con la pérdida ponderal. Pacientes y método: Estudio observacional de cohortes analíticas prospectivo, donde se incluyen 54 pacientes (27 por cada técnica quirúrgica) y un período de seguimiento de 12 meses. Se analizaron datos demográficos, datos antropométricos, comorbilidades, pérdida ponderal y evolución del comportamiento de ghrelina en ayunas. Resultados: Con ambas técnicas quirúrgicas el comportamiento de ghrelina acilada fue similar, sin diferencias significativas entre bypass gástrico y gastrectomía vertical. Con ambos procedimientos se produce un ascenso de ghrelina acilada al 5.o día y caída posterior, para luego ir ascendiendo hasta alcanzar valores superiores a los preoperatorios a los 12 meses. Este aumento en los niveles de ghrelina no afecta a la pérdida ponderal, ya que al año de la cirugía con las 2 técnicas quirúrgicas se alcanza un 30% de pérdida de peso. Conclusiones: Observamos un incremento de los niveles de ghrelina acilada en ayunas al año de seguimiento con ambas técnicas quirúrgicas, cuando existe una pérdida ponderal del 30%


Background and objective: Neuronal populations involved in the regulation of food intake, particularly the orexigenic (appetite-stimulating) hormone ghrelin, are found in the hypothalamus. Changes in plasma ghrelin levels have been observed following different bariatric surgery procedures, but the results from different studies are contradictory. Much remains unknown regarding the role of ghrelin in the weight loss process following bariatric surgery. Our objective was to describe the behaviour of fasting ghrelin levels, comparing the changes occurring between 2 different surgical techniques (gastric bypass versus vertical sleeve gastrectomy) and their correlation with weight loss. Patients and method: A prospective, observational, analytic cohort study of 54 patients (27 for each surgical technique) with a 12-month follow-up period. We analysed demographic data, anthropometric data, comorbidities, weight loss and evolution of fasting ghrelin. Results: The behaviour of acylated ghrelin was similar with the 2 surgical techniques, with no significant differences between gastric bypass and vertical sleeve gastrectomy. With both procedures, there was an increase in acylated ghrelin on day 5 and a subsequent decrease, and levels then gradually increased to reach values at 12 months that were higher than those reported preoperatively. This increase in ghrelin levels did not affect weight loss, since one year post-surgery, 30% weight loss was achieved with both types of surgery. Conclusions: We observed an increase in fasting acylated ghrelin levels at one year of follow-up with both surgical techniques, with 30% weight los


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Grelina/administração & dosagem , Estudos de Coortes , Derivação Gástrica , Gastrectomia , Cirurgia Bariátrica/métodos , Grelina/metabolismo , Estudos Prospectivos , Antropometria , Índice de Massa Corporal , Redução de Peso , Grelina/farmacologia
4.
Endocrinol Diabetes Nutr (Engl Ed) ; 67(2): 89-101, 2020 Feb.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31680051

RESUMO

BACKGROUND AND OBJECTIVE: Neuronal populations involved in the regulation of food intake, particularly the orexigenic (appetite-stimulating) hormone ghrelin, are found in the hypothalamus. Changes in plasma ghrelin levels have been observed following different bariatric surgery procedures, but the results from different studies are contradictory. Much remains unknown regarding the role of ghrelin in the weight loss process following bariatric surgery. Our objective was to describe the behaviour of fasting ghrelin levels, comparing the changes occurring between 2 different surgical techniques (gastric bypass versus vertical sleeve gastrectomy) and their correlation with weight loss. PATIENTS AND METHOD: A prospective, observational, analytic cohort study of 54 patients (27 for each surgical technique) with a 12-month follow-up period. We analysed demographic data, anthropometric data, comorbidities, weight loss and evolution of fasting ghrelin. RESULTS: The behaviour of acylated ghrelin was similar with the 2 surgical techniques, with no significant differences between gastric bypass and vertical sleeve gastrectomy. With both procedures, there was an increase in acylated ghrelin on day 5 and a subsequent decrease, and levels then gradually increased to reach values at 12 months that were higher than those reported preoperatively. This increase in ghrelin levels did not affect weight loss, since one year post-surgery, 30% weight loss was achieved with both types of surgery. CONCLUSIONS: We observed an increase in fasting acylated ghrelin levels at one year of follow-up with both surgical techniques, with 30% weight loss.


Assuntos
Jejum/sangue , Gastrectomia/métodos , Derivação Gástrica , Grelina/sangue , Obesidade Mórbida/sangue , Obesidade Mórbida/cirurgia , Redução de Peso , Adulto , Estudos de Coortes , Correlação de Dados , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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